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Diabetology Diabetes Therapy

Diabetes Therapy

Diabetes Therapy Guideline at a Glance

Understanding the new EMA guideline on medicinal products for diabetes

An overview of the revised European Medicines Agency guideline on the clinical investigation of medicinal products for the treatment or prevention of type 1 and 2 diabetes.

Editor's Choice

Using tirzepatide in clinical practice

Open Access Type 2 Diabetes Review

Practical advice on how to use tirzepatide in the management of type 2 diabetes, according to the clinical profile and therapeutic goals. Learn about adverse events, special warnings, precautions, and more.

Diabetes, anti-diabetic drugs, and premenstrual syndrome

Open Access Diabetes Review

PMS and diabetes share many physical and psychological symptoms, but what is the relationship between the two, and could anti-diabetic drugs have a favorable impact on the symptoms of PMS?

Improving outcomes in peripheral artery disease

Free for a limited time Peripheral Arterial Disease Review

A range of effective medical and non-medical interventions are available for treating peripheral artery disease, so why are major adverse cardiovascular and limb outcomes still so prevalent?

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Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Case Studies

Managing exogenous insulin antibody syndrome

Open Access Type 1 Diabetes Case Study

EIAS can cause hyperglycemia, hypoglycemia, and ketoacidosis in people with diabetes. This case in an older adult with type 1 diabetes shows how EIAS can be managed in an outpatient setting.

ICI-induced insulin-dependent diabetes without islet autoantibodies

Diabetes Case Study

Rapidly progressive insulin-dependent diabetes in the absence of islet autoantibodies developed 2 years after starting treatment with the immune checkpoint inhibitor nivolumab.

Nonketotic hyperglycemia hemichorea-hemiballismus

Open Access Type 2 Diabetes Case Study

HC-HB is a rare movement disorder that can occur in patients with poorly controlled diabetes and hyperglycemia without ketoacidosis. The mainstay of treatment is prompt correction of hyperglycemia.

Using CGM to optimize type 2 diabetes management with non-intensive insulin treatment in primary care

With the growing importance of primary care in diabetes, this podcast discusses the evidence on continuous glucose monitoring (CGM) use, the role of primary healthcare, and practical tips for interpreting the ambulatory glucose profile (AGP) report. 

Supported by: Abbott Diabetes Care

Prof. Samuel Seidu
Developed by: Adis

Current Reviews

The role of automated insulin delivery technology in diabetes

Open Access Insulins Review

The role of automated insulin delivery systems in diabetes is expanding. Hybrid closed-loop systems are being used in routine clinical practice for treating people with type 1 diabetes. Encouragingly, real-world data reflects the performance and …

Safety and efficacy of GLP-1 and glucagon receptor dual agonist for the treatment of type 2 diabetes and obesity: a systematic review and meta-analysis of randomized controlled trials

Obesity Review

The escalating prevalence of type 2 diabetes mellitus (T2DM) has become a pressing public health issue, with projections indicating a substantial increase in diagnosed cases over the next two decades [ 1 ]. Similarly, the World Health Organization …

Cardiovascular Benefits of GLP-1 Receptor Agonists in Patients Living with Obesity or Overweight: A Meta-analysis of Randomized Controlled Trials

Obesity Systematic Review

Obesity is a multifaceted condition, with an increasing incidence and prevalence worldwide [ 1 ]. Treatment options for obesity are currently limited, and the condition is associated with a higher risk of dyslipidemia, type 2 diabetes mellitus …

The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges

Insulins Review

In recent years, the potential of stem cells (SCs) to differentiate into various types of cells, including β-cells, has led to a significant boost in development. The efficiency of this differentiation process and the functionality of the cells …

Episode 10: Disease-modifying therapy for type 1 diabetes

Reducing the burden of type 1 diabetes

Despite many recent advances in its management, type 1 diabetes remains a burden for those living with the condition.

Prof. Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape.

Prof. Chantal Mathieu

Tweetorials | Vodcasts | Infographics (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)

Stay up to date with the rapidly changing CGM landscape. Learn how to implement and integrate CGM into diabetes management to improve patient care and outcomes.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Vodcasts | Case Scenarios (Link opens in a new window)

Expert guidance on the multidisciplinary approach to identifying and managing chronic kidney disease in patients with type 2 diabetes, plus patient scenarios to assist your decision-making and put the latest clinical guidelines into context.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Webcast | Videos (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Discussion-based webcast addressing the causes of clinical inertia in type 2 diabetes.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME
Insulins Clinical Trial Summary

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.

Developed by: Springer Medicine

Further Reading

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Open Access Insulins Original Research

Diabetes is a metabolic disorder characterised by the inability of pancreatic beta cells to control blood glucose levels. The aetiology of the most common form, type 2 diabetes, is heterogeneous, although population genetic studies have identified …

An analysis of the association between breast density and body mass index with breast cancer molecular subtypes in early breast cancer: data from a Spanish population

Open Access Breast Cancer RESEARCH ARTICLE

Breast cancer continues to be an important health problem and is one of the most common causes of cancer deaths in women worldwide, with an estimated 358,967 new cases and 90,665 breast cancer-related deaths in the European Union annually [ 1 ].

The Effect of Various Degrees of Renal or Hepatic Impairment on the Pharmacokinetic Properties of Once-Weekly Insulin Icodec

Open Access Insulins Original Research Article

Impaired renal function is a common long-term complication of diabetes mellitus as up to 40% of individuals with diabetes develop chronic kidney disease [ 1 , 2 ]. It is well known that renal impairment can alter drug pharmacokinetics, potentially …

The effect of PAP on UACR and metabolic indexes in patients with MS and OSAHS

Open Access Sleep Apnea Sleep Breathing Physiology and Disorders • Original Article

Due to unhealthy dietary habits, sedentary lifestyles, and irregular work-rest routines, the prevalence of Metabolic Syndrome (MS) in China has seen a steady increase in recent years. According to data from the Chinese Center for Disease Control …