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Type 1 Diabetes 

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  1. 14-03-2024 | Type 1 Diabetes | OriginalPaper

    Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India

    India accounts for most of the children with Type 1 diabetes (T1D) in South-East Asia [ 1 ]. A remarkably high prevalence of celiac disease (CD) among T1D is also seen in India, ranging from 11 to 13.5% [ 2 , 3 ] compared to the diabetic European …

  2. 19-03-2024 | Type 1 Diabetes | OriginalPaper

    Associations between daily step count classifications and continuous glucose monitoring metrics in adults with type 1 diabetes: analysis of the Type 1 Diabetes Exercise Initiative (T1DEXI) cohort

    Achieving the guidelines of 150 minutes of moderate to vigorous physical activity per week is associated with maintenance of whole-body insulin sensitivity, lower total daily insulin needs, improved cardiovascular health and weight maintenance in …

  3. 02-05-2024 | Type 1 Diabetes | Online First

    A case report of type 1 diabetes mellitus coexistent with Charcot–Marie–Tooth type 1A and a literature review

    Charcot–Marie–Tooth disease (CMTD), also known as hereditary motor sensory neuropathy, is a common group of single-gene hereditary neuropathy characterized by chronic progressive exacerbation of distal limb weakness, sensory abnormalities, and …

  4. 25-04-2024 | Type 1 Diabetes | Online First

    Vitamin D efficacy in type 1 and type 2 diabetes

    It is well known that vitamin D has a profound effect on calcium and bone metabolism, but its influence on other organs (extraskeletal effect) has been proposed. Consistently, vitamin D deficiency is associated with an increased incidence of …

  5. Open Access 01-12-2024 | Type 2 Diabetes | OriginalPaper

    Perceptions of diabetes distress during pregnancy in women with type 1 and type 2 diabetes: a qualitative interpretive description study

    For women with pre-existing diabetes who become pregnant, diabetes management will be at the center of their pregnancy journey. Pre-existing diabetes is type 1 diabetes (T1D) or type 2 diabetes (T2D) that is present before pregnancy and pregnancy …

  6. Open Access 20-02-2024 | Hypoglycemia | OriginalPaper

    Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study

    Despite a century of development and refinement of insulin therapy, hypoglycaemia remains the most common complication, affecting virtually all people with type 1 diabetes and most of those with insulin-treated type 2 diabetes [ 1 ]. Thus, people …

  7. 15-05-2024 | Type 2 Diabetes | Online First

    The link between serum neuregulin-1 and atherogenic index in type 2 diabetes mellitus

    Type 2 diabetes mellitus (T2DM) is a common metabolic disease marked by persistently high blood sugar levels and changes in the metabolism of proteins, lipids, and carbohydrates as a result of deficiencies in the secretion and/or action of insulin …

  8. Open Access 01-12-2024 | Type 1 Diabetes | OriginalPaper

    Alexithymia, intolerance to uncertainty and mental health difficulties in adolescents with Type 1 diabetes mellitus

    The literature suggests that various psychological and mental health variables impact complex medical conditions [ 1 – 6 ]. Among the relevant studies in this field, some authors focus in particular on the role of psychological variables in the …

  9. Open Access 20-04-2024 | Type 1 Diabetes | OriginalPaper

    Effects of Two COVID-19 Lockdowns on HbA1c Levels in Patients with Type 1 Diabetes and Associations with Digital Treatment, Health Literacy, and Diabetes Self-Management: A Multicenter, Observational Cohort Study Over 3 Years

    During the recent coronavirus disease 2019 (COVID-19) pandemic, nationwide lockdowns were imposed in most countries to contain the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 1 – 4 ]. Patients with diabetes mellitus …

  10. 05-05-2024 | Celiac Disease | Online First

    Evaluation of genetic association between celiac disease and type 1 diabetes

    Celiac disease (CD) is a chronic autoimmune disorder caused by gluten consumption in individuals with specific HLA risk factors (HLA-DQ2 and HLA-DQ8), leading to small intestinal damage and nutrient malabsorption [ 1 – 3 ]. CD presents with a …

  11. 03-05-2024 | Type 1 Diabetes | Online First

    From pediatric to adult care: a survey on the transition process in type 1 diabetes mellitus and the diabetes services in Italy

    Type 1 diabetes mellitus (T1D) is one of the most prevalent chronic conditions during childhood. Its incidence and prevalence have steadily increased worldwide, posing a growing burden on public health [ 1 ].

  12. 15-05-2024 | Type 1 Diabetes | Online First

    The interlink between thyroid autoimmunity and type 1 diabetes and the impact on male and female fertility

    The aim of this review is to discuss the several interconnections between thyroid autoimmunity and type 1 diabetes in terms of epidemiology, immunoserology, genetic predisposition, and pathogenic mechanisms. We will also analyze the impact of …

  13. 09-05-2024 | Type 1 Diabetes | Online First

    Skeletal fragility in type 1 diabetes mellitus: A rare case of avascular necrosis of talus

    People living with type 1 diabetes (T1D) have been reported to have 22–37% lower bone mineral density with up to four times greater risk of fractures [ 1 ]. Multiple complex mechanisms are responsible for this increased skeletal fragility including …

  14. 18-05-2024 | Online First

    Expecting factors for inadequate glycemic control in children and adolescents with type 1 diabetes mellitus: a single center experience

    Type 1 diabetes is an autoimmune disease, caused by the destruction of pancreatic islet cells. hence, absolute insulin deficiency [ 1 ]. Affected individuals have hyperglycemia and are susceptible to acute complications from hypoglycemia and …

  15. 18-05-2024 | Online First

    Clinical and functional characterization of a novel KCNJ11 (c.101G > A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13

    In 2012, based on whole-exome sequencing, the Illumina-Golden Gate assay, and linkage analysis techniques, Bonnefond et al. [ 1 ] reported that the KCNJ11 gene was identified and reported as a new MODY-causing gene isoform for the first time. Since …

  16. Open Access 01-12-2024 | Insulins | OriginalPaper

    Understanding suboptimal insulin use in type 1 and 2 diabetes: a cross-sectional survey of healthcare providers who treat people with diabetes

    Achieving optimal glycemic outcomes is critical for effective management of diabetes, and basal-bolus treatment regimens are currently seen as the standard of care for insulin injection therapy for fasting and post-prandial glucose in people with …

  17. Open Access 08-05-2024 | Type 1 Diabetes | Online First

    Reduced expression of central innate defense molecules in pancreatic biopsies from subjects with Type  1 diabetes

    Defensins are small molecules (2–5 kDa) that play an important role in the innate and adaptive defence system. They belong to a large family of antimicrobial peptides of ancient conservation. Humans express two subfamilies, Alpha- and …

  18. 01-05-2024 | Diabetes | OriginalPaper

    Linarin Ameliorates Restenosis After Vascular Injury in Type 2 Diabetes Mellitus via Regulating ADAM10-Mediated Notch Signaling Pathway

    Vascular lesions frequently arise as complication in patients diagnosed with diabetes mellitus (DM). Presently, percutaneous coronary intervention (PCI) and antithrombotic therapy serve as primary treatments. However, in-stent restenosis persists …

  19. Open Access 01-12-2024 | Type 2 Diabetes | OriginalPaper

    Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus

    Diabetes mellitus (DM) is characterized by chronic hyperglycaemia that leads to heterogenous disturbances of metabolism [ 1 ] and its continuing rise is a major concern in society [ 2 ]. DM is one of the main risk factors for cardiovascular disease …

  20. Open Access 10-04-2024 | Type 1 Diabetes | OriginalPaper

    Associations Between HbA1c and Glucose Time in Range Using Continuous Glucose Monitoring in Type 1 Diabetes: Cross-Sectional Population-Based Study

    The main objectives of treating diabetes mellitus are to optimize glucose levels to prevent hypo- and hyperglycemia, counteract the development of micro- and macrovascular diseases, and strive for a high quality of life. For over 40 years …

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