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933 search results for:

Antiandrogens 

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  1. 01-07-2019 | Prostate Cancer | OriginalPaper

    Comparative assessment of prognostic outcomes between first-generation antiandrogens and novel androgen-receptor-axis-targeted agents in patients with non-metastatic castration-resistant prostate cancer

    Androgen deprivation therapy (ADT) has been regarded as the mainstay for the treatment of patients with advanced prostate cancer (PC) as well as one of the major therapeutic options after the biochemical recurrence in localized PC patients treated …

  2. 01-10-2016 | News

    Antiandrogens increase risk of dementia

  3. 01-07-2017 | OriginalPaper

    Treat androgenetic alopecia with antiandrogens, as well as other pharmacological and non-pharmacological interventions

    Androgenetic alopecia (AGA) is the most common hair loss disorder. Options used to treat AGA in men and/or women include antiandrogens, minoxidil, prostaglandin analogues and antagonists and other interventions; however, most are not specifically …

  4. 01-11-2002 | Abstract

    Hypersensitivity pneumonitis a class effect of nonsteroidal antiandrogens

  5. 01-10-2012 | Abstract

    Health Canada concludes from a recent safety review that hepatotoxicity remains an important safety concern for patients using antiandrogens

  6. 01-08-1999 | OriginalPaper

    Antiandrogens in Prostate Cancer

    Antiandrogens competitively inhibit ligand binding to the androgen receptor (AR), and are used therapeutically in prostate cancer patients. The AR functions as a ligand dependent transcription factor that transduces androgen binding into increased …

  7. 01-05-1998 | ReviewPaper

    Clinical Pharmacokinetics of the Antiandrogens and Their Efficacy in Prostate Cancer

    Prostatic cancer is the second most common cause of cancer death in males. Treatment by radical prostatectomy and radiotherapy is useful in the early stages of the disease. Whenever metastases occur, patients are usually treated by surgical …

  8. 01-08-2006 | OriginalPaper

    What implications do the tolerability profiles of antiandrogens and other commonly used prostate cancer treatments have on patient care?

    An increased awareness of prostate cancer and improved diagnostic techniques mean that the disease is being detected at an earlier stage and in younger men than ever before. Although improved staging techniques have benefited patients in terms of …

  9. 01-06-2010 | OriginalPaper

    Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants

    A crucial event in prostate cancer progression is the transition from a hormone-sensitive to a lethal castration-refractory disease state. The antagonist-to-agonist conversion due to mutation in AR is a critical problem with the current clinically …

  10. Open Access 01-12-2012 | OriginalPaper

    Tamoxifen for the management of breast events induced by non-steroidal antiandrogens in patients with prostate cancer: a systematic review

    Prostate cancer growth is influenced by androgenic activity [ 1 ], and androgen suppression therapy is a non-curative therapeutic option for locally advanced, non-metastatic, lymph-node positive, symptomatic or asymptomatic metastatic prostate …

  11. 01-08-2019 | Prostate Cancer | News

    Abiraterone acetate/antiandrogens

    Paraneoplastic Cushing syndrome secondary to neuroendocrine prostate cancer: case report
  12. 01-06-2022 | Prostate Cancer | ReviewPaper

    Evaluation of maintenance of the common androgen deprivation therapy with the new antiandrogen therapy in patients with castration-resistant prostate cancer: a systematic review

    Prostate cancer (PC) is the most common cancer in men worldwide and the second leading cause of cancer death, behind only lung cancer deaths. The American Cancer Society (ACS) estimates for 2021 about 248,530 new cases, and around 34,130 deaths …

  13. 08-04-2024 | Prostate Cancer | Online First

    Psoas mass index at the level of the third lumbar vertebra on computed tomography is a prognostic predictor for metastatic castration-sensitive prostate cancer

    A low skeletal muscle mass (LSMM), measured using imaging modalities, has been reported to be associated with poor oncological outcomes in various cancers (including prostate cancer [PCa]) [ 1 ]. LSMM is defined as the skeletal muscle mass with two …

  14. Open Access 17-03-2024 | Prostate Cancer | OriginalPaper

    Androgen deprivation therapy-related fracture risk in prostate cancer: an insurance claims database study in Japan

    Worldwide, prostate cancer (PC) is the second most prevalent type of cancer in men. In 2020, an estimated 1.4 million new cases and 375,304 PC-related deaths occurred worldwide [ 1 ]. In Japan, the age-standardised incidence rate for 2020 was 51.8 …

  15. Open Access 20-04-2024 | Prostate Cancer | Online First

    Psychosocial Factors Associated with Cognitive Function in Prostate Cancer Survivors on Hormonal Treatments: A Systematic Review

    Hormonal treatments (HT) for prostate cancer (e.g., androgen deprivation therapy) yield clinical and survival benefits, yet adverse cognitive changes may be a side effect. Since psychosocial factors are largely modifiable, interventions targeting …

  16. Open Access 01-12-2024 | Heart Failure | OriginalPaper

    Real-world data of cardio-oncologic interventions for cardiovascular adverse events with oral oncolytics

    As research continues to elucidate the cellular signaling pathways responsible for malignant cell transformation, the development of oral oncolytics in recent years has exponentially increased. Between March 2009 and May 2022, the US Food and Drug …

  17. 11-10-2023 | OriginalPaper

    Isocaloric diet is as effective as the hypocaloric diet in ameliorating symptoms in PCOS patients

    PCOS is a common disorder of the reproductive age group presenting with varying degrees of hirsuitism and oligoanovulation. Obesity can exacerbate the metabolic and reproductive abnormalities that are associated with the disorder. Weight loss in …

  18. Open Access 01-12-2020 | Prostate Cancer | OriginalPaper

    Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report

    Various drugs, such as second-generation antiandrogens, radium-223, and cabazitaxel, have been approved for treatment of castration-resistant prostate cancer (CRPC) in many countries, including Japan. However, the duration of response to these …

  19. 01-04-2024 | Bicalutamide | News

    Bicalutamide

    Hepatotoxicity and off-label use
  20. 01-12-2020 | Polycystic Ovary Syndrome | OriginalPaper

    Oral contraceptives increase platelet microparticle levels in normal-weight women with polycystic ovary syndrome

    Polycystic ovary syndrome (PCOS) is the commonest endocrinopathy in women of reproductive age, characterized by oligo- or anovulation, biochemical and/or clinical hyperandrogenemia, and polycystic ovaries on ultrasound. Oral contraceptives (OCPs) …

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